By Stephanie7 Added at June 22, 2011 Views 2,350 Reviews 4

Generic Name: fluoxetine and olanzapine (floo OX eh teen and oh LAN za peen)
Brand Names: Symbyax

Symbyax is used to treat depression caused by bipolar disorder (manic depression). Symbyax is also used to treat depression after at least 2 other medications have been tried without successful treatment of symptoms.

combines an atypical antipsychotic and a selective serotonin reuptake inhibitor, olanzapine (the active ingredient in Zyprexa, and Zyprexa Zydis) and fluoxetine hydrochloride (the active ingredient in Prozac, Prozac Weekly, and Sarafem).

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Reviews (2 reviews)

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bolyla August 22, 2012 at 5:20 am   

I was but on Symbyax. I stayed on it for almost a year. The doctor said I'd gain 20 pounds, but in reality I gained 126 pounds. I was miserable. I went off it in Jan, 2012 and I've lost 85 pounds of what I had gained.

Stephanie7 June 22, 2011 at 8:49 pm   

You get the synergistic effect of an antipsychotic and antidepressant in one pill without your doctor trying to figure out how much of which two to give you. The olanzapine and fluoxetine combination has had the most studies and is a truly potent combination. It’s one pill and prescription instead of two. There’s not as much stigma attached to an antidepressant as there is to an antipsychotic. Even if Symbyax doesn’t work out for someone it introduces the concept of the antipsychotic and antidepressant cocktail - even if it’s not the first AD & AP combo in one pill - as a means to treat bipolar and refractory unipolar depression, and for that reason alone this pill is a huge breakthrough.

I have been on countless anti-depressants, and this is the only one that has ever worked for me. My doctor told me this one is for "treatment resistant depression."


The usual for SSRIs and atypical antipsychotics - headache, weight gain, nausea, weight gain, dry mouth, weight gain, sweating, weight gain, sleepiness or insomnia, weight gain, diarrhea or constipation, weight gain, and loss of libido. Did I mention weight gain? Most everything will go away after a week or two, but the sleepiness, weight gain and loss of libido might stick around longer.

Only side effect I had was weight gain. About 10lbs. But I was on the max dose, so a lower dose wouldn't be so bad.

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